Volume 3 Supplement 1

6th German Conference on Chemoinformatics, GCC 2010

Open Access

Studies on the mechanism of the lactide polymerization with highly active zinc guanidine catalysts

  • I dos Santos Vieira1,
  • J Börner2,
  • U Flörke2 and
  • S Herres-Pawlis1Email author
Journal of Cheminformatics20113(Suppl 1):P22

DOI: 10.1186/1758-2946-3-S1-P22

Published: 19 April 2011

Polylactide (PLA) is a biodegradable polyester which is able to replace petrochemical based plastics in many fields [1]. It is commonly produced by ring-opening polymerisation (ROP) of the cyclic diester lactide with metal containing initiator systems using anionic ligand systems [2].

Zinc complexes with neutral guanidine ligands have proven to be highly active initiators in the ROP of lactide [3, 4]. In an integrated study combining kinetic analyses, spectroscopic measurements and DFT calculations the mechanism of the lactide polymerisation with this special catalyst class could be clarified. We could show that the polymerisation proceeds via a coordination-insertion-mechanism.

A complete reaction coordinate diagram including enthalpies of intermediates and transition states could be compiled by B3LYP-DFT for the initiation step of the polymerisation with the initiator [Zn(TMGqu)2(CF3SO3)][CF3SO3] and also for the chain propagation. The initiating step includes three transition states with 102 kJ/mol as highest activation barrier. The model for the propagation step reveals two transition states with an energy barrier not exceeding 65 kJ/mol. The results of this study demonstrate that lactide ROP proceeds not only with classical complexes using anionic ligands, but also with complexes containing neutral but highly nucleophilic guanidine ligands.

Authors’ Affiliations

(1)
Anorganische Chemie II, Technical University of Dortmund
(2)
University of Paderborn

References

  1. Gupta B, Revagade N, Hilborn J: Poly(lactic acid) fiber: An overview. Prog Polym Sci. 2007, 32: 455-482. 10.1016/j.progpolymsci.2007.01.005.View ArticleGoogle Scholar
  2. Dechy-Cabaret O, Martin-Vaca B, Bourissou D: Controlled Ring-Opening Polymerization of Lactide and Glycolide. Chem Rev. 2004, 104: 6147-6176. 10.1021/cr040002s.View ArticleGoogle Scholar
  3. Börner J, Flörke U, Huber K, Döring A, Kuckling D, Herres-Pawlis S: Lactide Polymerisation with Air-Stable and Highly Active Zinc Complexes with Guanidine-Pyridine Hybrid Ligands. Chem Eur J. 2009, 15: 2362-2376.View ArticleGoogle Scholar
  4. Börner J, Herres-Pawlis S, Flörke U, Huber K: [Bis(guanidine)]zinc Complexes and Their Application in Lactide Polymerisation. Eur J Inorg Chem. 2007, 5645-5651.Google Scholar

Copyright

© dos Santos Vieira et al; licensee BioMed Central Ltd. 2011

This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.