Volume 6 Supplement 1

9th German Conference on Chemoinformatics

Open Access

Scaffold hunter: visual analysis of biological activity data

  • Karsten Klein1,
  • Oliver Koch2Email author,
  • Nils Kriege3,
  • Petra Mutzel3 and
  • Till Schäfer3
Journal of Cheminformatics20146(Suppl 1):P33

DOI: 10.1186/1758-2946-6-S1-P33

Published: 11 March 2014

The growing interest in chemogenomics approaches over the last years has led to a vast amount of data regarding chemical and the corresponding biological activity space. The discovery of new chemical entities is not suitable to a fully automated analysis, but can greatly benefit from tools that allow exploring this chemical and biological space. We present a new version of Scaffold Hunter [1, 2], a highly interactive tool that fosters the systematic visual exploration of compound and bioactivity data. The software supports the integration of data from various sources and provides several complementary analysis and visualization modules (Figure 1).
Figure 1

Iterative Workflow.

Scaffold Hunter features the scaffold tree algorithm to provide hierarchical classification schemes and offers several interconnected views reflecting different aspects of the data. As a further extension state of the art clustering techniques are now included that allow, for example, to create subsets based on fingerprint similarity. A key concept of Scaffold Hunter is to support a cyclic, iterative knowledge discovery process, where it is possible to refine subsets, adjust the parameters of analysis algorithms or the mapping of property values to visual attributes.

We give an overview over the various views, the workflow concept and present an exemplary analysis of screening datasets targeting T. cruzi and T. brucei, the causative agent of sleeping sickness and Chagas disease, respectively. Scaffold Hunter is platform-independent and freely available under the terms of the GNU GPL v3 at http://scaffoldhunter.sourceforge.net/.

Authors’ Affiliations

(1)
School of Information Technologies, The University of Sydney
(2)
Department of Chemistry and Chemical Biology, TU Dortmund
(3)
Department of Computer Science, TU Dortmund

References

  1. Wetzel S, Klein K, Renner S, Rauh D, Oprea TI, Mutzel P, Waldmann H: Interactive exploration of chemical space with Scaffold Hunter. Nat Chem Biol. 2009, 5: 581-583. 10.1038/nchembio.187.View ArticleGoogle Scholar
  2. Klein K, Koch O, Kriege N, Mutzel P, Schäfer T: Visual Analysis of Biological Activity Data with Scaffold Hunter. Mol Inf. 2013,Google Scholar

Copyright

© Klein et al; licensee Chemistry Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.