Volume 6 Supplement 1

9th German Conference on Chemoinformatics

Open Access

Is there a sodium effect in fibrillar amyloid-β oligomers?

Journal of Cheminformatics20146(Suppl 1):P56

https://doi.org/10.1186/1758-2946-6-S1-P56

Published: 11 March 2014

Hall mark in Alzheimer’s Disease (AD) is the aggregation of amyloid-β (Aβ) peptide into oligomers and fibrils. Nowadays, the soluble oligomers are believed to be the most neurotoxic species, probably the causative agents in AD. Amyloid-beta fibrils on the other hand may serve as reservoirs for small toxic oligomers. While it is well known from experiment, that the aggregation process is modulated by salt concentration in solution, the molecular details of the underlying interactions are not.

Salts occur ubiquitously in physiological environments and are known to have profound effects on the solubility of proteins (Hofmeister series). Monovalent alkali metal ions exhibit a more subtle effect on Aβ aggregation in experiment than doubly charged species [1, 2].

In this contribution we investigate the presence of the so-called ‘sodium-effect’ in fibrillar Aβ oligomers. This effect was originally described for dendrimer micelles formation modulating the self-organization of amphiphilic carboxylates: Na+ forms bridging complexes with carboxylate groups, in contrast to K+ [3].

Molecular dynamics simulations for a systematic series of single and double layer fibrillar Aβ oligomers in aqueous 150mM salt solution provide insights about the stabilizing interactions between the cations and charged Aβ key residues (e.g. Glu22). Comparison with a previous computational study at low ion concentration [4] show similarities and differences on a structural level. Interestingly, ions access the Aβ water channel region via entry paths suggested previously [4].

Authors’ Affiliations

(1)
Bioinformatik, Institut für Biochemie, Friedrich-Alexander-Universität Erlangen-Nürnberg

References

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Copyright

© Horn et al; licensee Chemistry Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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