Volume 7 Supplement 1
LeadMine: a grammar and dictionary driven approach to entity recognition
© Lowe and Sayle; licensee Springer. 2015
Published: 19 January 2015
Chemical entity recognition has traditionally been performed by machine learning approaches. Here we describe an approach using grammars and dictionaries. This approach has the advantage that the entities found can be directly related to a given grammar or dictionary, which allows the type of an entity to be known and, if an entity is misannotated, indicates which resource should be corrected. As recognition is driven by what is expected, if spelling errors occur, they can be corrected. Correcting such errors is highly useful when attempting to lookup an entity in a database or, in the case of chemical names, converting them to structures.
Our system uses a mixture of expertly curated grammars and dictionaries, as well as dictionaries automatically derived from public resources. We show that the heuristics developed to filter our dictionary of trivial chemical names (from PubChem) yields a better performing dictionary than the previously published Jochem dictionary. Our final system performs post-processing steps to modify the boundaries of entities and to detect abbreviations. These steps are shown to significantly improve performance (2.6% and 4.0% F1-score respectively). Our complete system, with incremental post-BioCreative workshop improvements, achieves 89.9% precision and 85.4% recall (87.6% F1-score) on the CHEMDNER test set.
Grammar and dictionary approaches can produce results at least as good as the current state of the art in machine learning approaches. While machine learning approaches are commonly thought of as "black box" systems, our approach directly links the output entities to the input dictionaries and grammars. Our approach also allows correction of errors in detected entities, which can assist with entity resolution.
With the rapidly increasing volume of scientific publications machine assisted knowledge extraction is becoming a necessity. Entity recognition allows the association of concepts with a document such as a research article, patent or thesis. Knowledge of the position of entities within text facilitates higher level relationship extraction (e.g. associating quantities with chemical entities), identifying interactions between chemicals and other entity types (e.g. chemical-protein), determining the role of chemicals in a chemical reaction etc. All such activities work best when the chemical entity recognition step has both high recall and precision.
To test the current state of the art in chemical entity recognition, and drive further innovation in the field, BioCreative IV introduced the Chemical compound and drug name recognition task (CHEMDNER) . This task consisted of a corpus of 10,000 PubMed abstracts that were annotated by domain experts to provide a gold standard. 3,500 of these were released to task participants as the "training corpus" with a further 3,500 released as the "development corpus". These 7,000 abstracts were used by participants to train and validate their solutions. The remaining 3,000 abstracts formed the test set and were provided to participants (along with 17,000 decoy abstracts) so that they could predict the entities that were annotated by the domain experts.
Attempts to tackle the problem of chemical entity recognition have invariably identified that the problem is not amenable to pure dictionary approaches due to the continuing discovery of novel compounds and the many ways in which systematic nomenclature allows compounds to be named . Hence, state of the art systems use machine learning techniques to learn weights for pre-engineered features indicative of chemical nomenclature, e.g. character sequences, word morphology, features of surrounding words etc. Examples include OSCAR4 which employs a maximum-entropy Markov model , and ChemSpot which employs a conditional random field model . Comprehensive reviews of the area have been performed by Vazquez et al.  and Gurulingappa et al. .
LeadMine instead encodes the rules used to describe systematic chemical nomenclature (as grammars), with large dictionaries being used for trivial names (unsystematic names). Compared to machine learning approaches this makes the results easily understandable; false positives can be pin-pointed to a particular grammar/dictionary and false negatives are readily corrected by adding the relevant nomenclature rule to a grammar or trivial name to a dictionary.
A normalization step is performed to address the issue of there being many Unicode characters with similar meaning. For example `(backtick), ‘ and ’ (single quotation marks) and ′ (prime) are all converted to apostrophe. Another example is œ which is converted to oe. This step reduces the number of superficial variants that dictionaries/grammars need to match. The indexes of characters in the original string are associated with indexes in the normalized string to allow mapping back to the original input.
The normalization step also facilitates processing of XML documents by removing stylistic tags and considering all other tags as delimiting paragraphs. For example, <p>H<sub>2</sub>O</p> is normalized to H2O. The ability to handle XML input was, except in a handful of cases, irrelevant to PubMed abstracts.
The rules for chemical nomenclature are encoded as formal grammars, e.g.
alkaneStem : 'meth' | 'eth' | 'prop' …
alkane: alkaneStem 'ane'
To efficiently match against our grammars we convert them to finite-state machines .
Digit1to9 : '1' | '2' |'4' |'5' |'6' |'7' |'8' |'9'
Digit : Digit1to9 | '0'
Cid : 'CID:' Digit1to9 Digit*
The state machine representation restricts us to the subset of rules that may be expressed by a regular grammar, e.g. a rule may not reference itself. As correct nesting of brackets is not generally possible with this constraint, while matching characters against a dictionary a record of the brackets seen is kept. A valid dictionary match is required to have well-nested balanced brackets.
Due to the complexity of IUPAC nomenclature it is impractical to build a single state machine that covers all IUPAC nomenclature while still rejecting syntactically invalid chemical names. Hence, our systematic chemical grammars are represented as a state machine in which the transitions, instead of corresponding to characters, correspond to other state machines (in which transitions do correspond to characters). This separation allows the main state machine to keep track of overall state while the other state machines match actual text. For example, which characters are allowed after seeing the substituent 'ethyl' differs between 'ethylbenzene' and 'acetic acid ethyl ester'. By storing this distinction in the main state machine we can use the same state machine to match 'ethyl' in both cases, despite the difference in context.
Other chemical entity types recognized by LeadMine using grammars.
Line formula (complete molecule)
Line formula (linker)
Line formula (substituent)
The PubChem dictionary is our primary source of trivial names. It contains 1.48 million terms. It was produced by running a series of filters against the unfiltered list of synonyms provided by PubChem  (~100 million terms). As most synonyms in PubChem are database identifiers which are either not useful for text mining or are better expressed by grammar, the number of useful synonyms is far smaller.
Previous work in the area of chemical dictionary preparation by Hettne et al.  indicated PubChem to be the chemical database whose synonyms had highest recall. However the use of synonyms from this database was hampered by such poor precision that it was not used in their final ensemble dictionary (Jochem). To address this we developed an extensive series of filters to remove ambiguous (could be a chemical name but typically was not) and incorrect (protein names, non-chemical English words etc.) synonyms without significantly lowering the recall. A comparison between Jochem and our dictionary is discussed later.
The following filters and term expansion rules were applied:
Reject if the associated structure was determined to be a tetrasaccharide (or longer) or hexadecapeptide (or longer). This conformed to the letter of the CHEMDNER annotation guidelines.
Reject if contains unbalanced brackets
Remove superfluous bracketed qualifiers, e.g. '(INN)'. Reject if the qualifier is unknown.
Reject if preceded/followed by a qualifier, e.g. 'derivative', 'analog', 'solution'
Reject if ≤ 3 characters
Reject if starts or ends with a hyphen
Reject if contains a comma followed by a space
Reject if matched by another LeadMine dictionary
Reject if is a known dubious synonym, e.g. 'AstraZeneca'
Reject if the first word is a non-chemical English word unless the next word is 'acid'
Reject if contains a dubious word, e.g. 'gene', 'inhibitor'
Reject if the name is a depositor's external name, i.e. it is a catalogue number
Reject if a regular expression for common catalogue numbers matches
Reject if contains any of the following characters ? ! \ | % @ ;
Reject if is a protein data bank (PDB) code
Reject if is an InChI key
If contains Greek letters written out in Latin characters, e.g. 'alpha-' generate a variant that instead uses the Greek character, e.g. 'α-'
If the last word consists of digits, generate variants where the preceding space is deleted or replaced by a hyphen, e.g. 'KF 17837' will also give 'KF-17837' and 'KF17837'
If the last word is a letter or letter followed by a digit, generate variants where the preceding space is replaced by a hyphen, e.g. 'Bisphenol A' will also give 'Bisphenol-A'
Additional chemical dictionaries used by LeadMine.
Number of terms
Common chemical abbreviation
Common trivial chemical name
Generic chemical class
Generic chemical class from ChEBI
Derived from ChEBI  terms that are referenced in an "is a" relationship by another term
International Mineralogical Association names with some manual additions
Non-structural chemical classes
bronsted lowry acid
Manually constructed. Terms that do not strictly convey structural information but were nonetheless annotated in the corpus
One heavy atom substituent
polyethylene glycol 8000
Manually constructed. Biochemical polymers blocked by another dictionary
beefy meaty peptide
Terms from Wikipedia chemboxes not matched by our other dictionaries
None of the aforementioned dictionaries or grammars directly take advantage of the annotated corpus. Hence, we used the system's false negatives to derive a dictionary of terms to include (Include list) and the system's false positives to derive a dictionary of terms to exclude (Stop list). When evaluating our final system on the test set we used the union of the training and development sets to derive these dictionaries. Candidate terms were only included if they increased f-score on the combined training and development set (some false negative terms are highly ambiguous and their inclusion reduced precision more than the increase in recall).
The CHEMDNER annotation guidelines indicate that biopolymers should not be annotated but that synthetic polymers should be. As LeadMine's polymer dictionary does not make this distinction, we determined which of the entries in the dictionary were natural polymers and use these to produce a dictionary of terms to exclude. This distinction can become quite unclear, e.g. is an artificial derivative of a natural polymer synthetic?
While most chemical names can be determined to be chemical names without context, this is not the case for short chemical formulae. Obvious counter examples include 'In' (indium) and 'As' (arsenic). As such terms are usually of lesser importance anyway, we have not attempted to disambiguate their meaning from the context of their usage. Instead, we have simply used the training/development set corpora to derive which chemical formulae found by our system are more often false positives. The results of this were used as a dictionary of terms to exclude.
LeadMine supports performing edit operations to correct a potential entity, such that it then corresponds to an entity recognized by a grammar/directory. These edits may be character insertions, deletions, substitutions or transpositions. This correction process is facilitated by a refined version of the algorithm described by Sayle et al. . Common optical character recognition mistakes, typos (e.g. floro) and minor mistakes (e.g. erroneous space, comma instead of a period, missing hyphen) are assigned lower costs such that the algorithm may perform more of these correction operations. In the case that the algorithm suggests multiple corrections that yield recognized entities, the cost of the corrections is used to choose which is preferred.
Spelling correction may be customized on a per dictionary/grammar basis as to whether correction should be performed, how many unparameterized edits may be performed and how long an entity must be for spelling correction to be allowed. As PubMed abstracts generally have few actual errors, we restricted corrections to just the parameterized errors and enabled it on dictionaries that matched chemical name-like entities.
PubMed abstracts frequently contain novel trivial and semi systematic terms. This contrasts with patents (for which LeadMine was originally developed) where fully systematic names are more frequently used. Grammar based approaches work when the entities to be recognized are systematic in nature, while dictionaries cannot recognize novel terms.
Fortunately, in chemistry, many novel terms arise from combination or derivatization of known terms. For example complicated chemical family names, e.g. 'monoterpene pyridine alkaloids' may not appear in any lexicon but the individual components will. This example will be recognized as three distinct entities, which can then by an entity merging step be combined to give the entire entity. In other cases part of an entity may be recognized, e.g. in '(S)-nornicotine' nornicotine will be recognized and entity extension can then infer that the rest of the word is likely to be part of this entity.
Our entity modification process comprises the following steps:
1. Entity extension
Entities are extended until one of the following is reached: whitespace, a mismatched bracket or a non-chemical English word/noise word. Additionally if an entity was entirely enclosed in balanced brackets and entity extension starting from before and/or after the brackets yielded a longer entity we used these entity boundaries.
An exception was made for the case of two entities separated by a hyphen where both corresponded to specific compounds. In this case the end and start of the entities respectively are not extended and the entities are not merged. Such a construct often indicates a mixture, e.g. 'Resorcinol-Formaldehyde'.
2. Entity trimming
In accordance with the annotation guidelines, the start and end of entities are trimmed of "Non-essential parts of the chemical entity and name modifiers", e.g. 'group', 'colloidal', 'dye' etc.
3. Entity merging
Entities that overlap after entity extension are merged together. Entities that are space separated are merged together unless one of the entities is found to be an instance of the other entity. For example genistein isoflavonoid is not merged as genistein IS an isoflavonoid. These relationships are derived from the ChEBI  ontology.
4. Removal of stop words
The aforementioned entity trimming process is repeated. If after trimming an entity corresponds to a stop term it is excluded. An example is 'gold nanoparticles' where 'nanoparticles' is excluded by trimming and 'gold' is explicitly not to be annotated according to the annotation guidelines.
5. S-transferase special case
The 'S' in glutathione-S-transferase is annotated using its proximity to the glutathione entity.
We used an adapted version of the Hearst and Schwartz algorithm  to identify abbreviations of entities found by our system. By providing the "long form" (unabbreviated form) we avoid one of the issues with the algorithm, which is that it may not identify the complete unabbreviated form. We extended the algorithm to recognize abbreviations of the following forms:
THF = tetrahydrofuran
Abbreviations may contain brackets so long as they are balanced. The conditions described by Hearst and Schwartz are applied with the additional requirements that the short form must not be a common chemical identifier, e.g. '1a' or Roman numeral, e.g. 'II'. The minimum length of abbreviations is configurable and set to 3 for compliance with the annotation guidelines.
We also utilize a list of string equivalents to allow, for example, mercury to be abbreviated to Hg. Hence the algorithm knows that MeHg is a plausible abbreviation for methylmercury. Once an abbreviation has been detected all further instances of that string, in that particular document, are annotated.
All data in this section relates to the evaluation of the ability to find chemical entity mentions in the CHEMDNER test set. Results were calculated using the evaluation script provided by the task organizers and the same metrics used by the organizers (micro-averaged F1-score) are reported.
Post competition improvements
As our system already produced highly competitive results on the test corpus, improvements have been incremental in nature (Table 3). To keep the test corpus valid for testing, only the training/development sets were used to identify issues and performance improvements were validated against these sets. The following improvements each contributed about 0.1% f-score:
PubChem dictionary regenerated from latest synonym data
Improved precision of the PubChem dictionary by removing more ambiguous and incorrect synonyms
Generated additional dictionary entries that use the actual Greek characters rather than Latin characters, e.g. 'α' instead of 'alpha'
Turned on spelling correction on more of the dictionaries, e.g. PubChem
Improved the precision of the Chemical Formula grammar (Table 1) by limiting sum formulae to just those with more than two digits, e.g. CDK2, CaCo, HeLa are no longer recognized as sum formulae.
Fixed a few corner cases in entity extension, e.g. 'leucine-to-proline' is two entities
Results on the CHEMDNER test set.
LeadMine competition submission (2013-10-07)
Best competition submission
Include lists and stop lists
The addition of an include list dictionary trained from the training/development corpus provided a significant increase in recall (Figure 4) with only a minimal loss of precision. This indicates that there are still gaps in the coverage of the system's dictionaries and grammars. This include list (currently containing 2969 terms) could be used to suggest areas where the system should be improved. Broadly the terms in the list fall into the following categories:
Unusual trivial names, especially natural products, e.g. 'chikusetsusaponin L10', 'microgrewiapines A-C'
Short, potentially ambiguous, terms, e.g. 'AP5', 'WB2', 'ZIP'
Typographic errors, e.g. '(68) Ga(3+)' [erroneous space]
Unusual chemical family names, e.g. '1,6-Diyne Carbonates and Esters', 'Antimony-Doped Tin Oxide', 'cyclic tri- and tetra-amine disulfides'
A dictionary derived from a database that specializes in natural products may be beneficial for the first of these categories.
Memory usage also differs significantly between solutions, while OSCAR4.1 and LeadMine require less than 1GB, ChemSpot 2.0 requires either 15 or 9 GB depending on whether or not the multi-class tagger is used.
Entity modification gave a significant improvement in both recall and precision (Figure 4) due to reducing the number of partial entity hits (which count as false positives) and increasing the number of hits with the correct entity boundaries. However, depending on the use case this increase in performance could be artificial; in all cases where entities have been modified after matching there is likely to be a significant increase in the difficulty of resolving these terms. For example nornicotine will be in PubChem and hence resolvable to a structure, but (S)-nornicotine will not. Similarly systematic chemical names, prior to modification, are likely to be resolvable by chemical name to structure algorithms.
Trivial chemical name dictionaries
Jochem, out of the box, also possess a fair number of dubious terms (e.g. 'command', 'surpass', 'procure', 'optimizer') although it is overall a far cleaner resource than PubChem. Jochem's precision also benefited from the same filtering procedure we applied to PubChem although as structure information was not available for all terms we were unable to filter for long peptides/saccharides. Jochem contains indication of which terms should be treated case sensitively which we honored.
Jochem, both before and after filtering, has lower recall than our PubChem derived dictionary. Using the filtered PubChem and Jochem dictionaries in combination gave a negligible improvement in recall indicating that most of Jochem is a subset of PubChem. This is not entirely surprising as most of the databases that Jochem is aggregated from are PubChem depositors.
We have developed a fast high-precision solution to chemical entity recognition which differs from conventional machine learning approaches by being able to attribute all entities to a specific dictionary or grammar. As a result errors and omissions can be incrementally corrected. The use of dictionaries and grammars is not limited to chemistry allowing the system to recognize entities from other domains.
We would like to thank Sorel Muresan of AstraZeneca for motivating and funding the initial development of LeadMine.
Funding for publication was provided by NextMove Software Ltd.
This article has been published as part of Journal of Cheminformatics Volume 7 Supplement 1, 2015: Text mining for chemistry and the CHEMDNER track. The full contents of the supplement are available online at http://www.jcheminf.com/supplements/7/S1.
- Krallinger M, Rabal O, Leitner F, Vazquez M, Salgado D, Lu Z, Leaman R, Lu Y, Ji D, Lowe DM, Sayle RA, Batista-Navarro RT, Rak R, Huber T, Rocktaschel T, Matos S, Campos D, Tang B, Xu H, Munkhdalai T, Ryu KH, Ramanan SV, Nathan S, Zitnik S, Bajec M, Weber L, Irmer M, Akhondi SA, Kors JA, Xu S, An X, Sikdar UK, Ekbal A, Yoshioka M, Dieb TM, Choi M, Verspoor K, Khabsa M, Giles CL, Liu H, Ravikumar KE, Lamurias A, Couto FM, Dai H, Tsai RT, Ata C, Can T, Usie A, Alves R, Segura-Bedmar I, Martinez P, Oryzabal J, Valencia A: The CHEMDNER corpus of chemicals and drugs and its annotation principles. J Cheminform. 2015, 7 (Suppl 1): S2-View ArticleGoogle Scholar
- Klinger R, Kolarik C, Fluck J, Hofmann-Apitius M, Friedrich CM: Detection of IUPAC and IUPAC-like chemical names. Bioinformatics. 2008, 24: i268-10.1093/bioinformatics/btn181.View ArticleGoogle Scholar
- Jessop DM, Adams S, Willighagen EL, Hawizy L, Murray-Rust P: OSCAR4: a flexible architecture for chemical text-mining. J Cheminformatics. 2011, 41-Google Scholar
- Rocktäschel T, Weidlich M, Leser U: ChemSpot: a hybrid system for chemical named entity recognition. Bioinformatics. 2012, 28: 1633-1640. 10.1093/bioinformatics/bts183.View ArticleGoogle Scholar
- Vazquez M, Krallinger M, Leitner F, Valencia A: Text Mining for Drugs and Chemical Compounds: Methods, Tools and Applications. Mol Inform. 2011, 30: 506-519. 10.1002/minf.201100005.View ArticleGoogle Scholar
- Gurulingappa H, Mudi A, Toldo L, Hofmann-Apitius M, Bhate J: Challenges in mining the literature for chemical information. RSC Adv. 2013, 3: 16194-16211. 10.1039/c3ra40787j.View ArticleGoogle Scholar
- Sayle R, Xie PH, Muresan S: Improved Chemical Text Mining of Patents with Infinite Dictionaries and Automatic Spelling Correction. J Chem Inf Model. 2011, 52: 51-62.View ArticleGoogle Scholar
- Bolton EE, Wang Y, Thiessen PA, Bryant SH: PubChem: Integrated Platform of Small Molecules and Biological Activities. Annu Rep Comput Chem. Edited by: Ralph A Wheeler and David C. 2008, Spellmeyer Elsevier, 4: 217-241.Google Scholar
- Hettne KM, Stierum RH, Schuemie MJ, Hendriksen PJ, Schijvenaars BJ, van Mulligen EM, Kleinjans J, Kors JA: A Dictionary to Identify Small Molecules and Drugs in Free Text. Bioinformatics. 2009Google Scholar
- Degtyarenko K, de Matos P, Ennis M, Hastings J, Zbinden M, McNaught A, Alcantara R, Darsow M, Guedj M, Ashburner M: ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 2008, 36: D344-350.View ArticleGoogle Scholar
- Schwartz A, Hearst M: A Simple Algorithm for Identifying Abbreviation Definitions in Biomedical Text. Proc Pac Symp Biocomput Kauai. 2003, 451-462.Google Scholar
- Lowe DM, Sayle RA: LeadMine: A grammar and dictionary driven approach to chemical entity recognition. BioCreative Chall Eval Workshop. Washington. 2013, 2: 47-Google Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.